|
KMID : 0352720220460010138
|
|
Journal of Ginseng Research
2022 Volume.46 No. 1 p.138 ~ p.146
|
|
|
Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production
|
|
Hwang Soon-Kyung
Jeong Yun-Jeong
Cho Hyun-Ji
Park Yoon-Yub
Song Kwon-Ho
Chang Young-Chae
|
|
|
Abstract
|
|
|
Background: Red Ginseng has been used for many years to treat diseases. Ginsenoside Rg3 has documented therapeutic effects, including anticancer and anti-inflammatory activities. However, the anticancer effect of Rg3-enriched red ginseng extract (Rg3-RGE) and its underlying mechanisms have not been fully explored. We investigated whether Rg3-RGE plays an anti-tumor role in lung cancer cells.
Methods: To examine the effect of Rg3-RGE on lung cancer cells, we performed cell viability assays, flow cytometry, western blotting analysis, and immunofluorescence to monitor specific markers.
Results: Rg3-RGE significantly inhibited cell proliferation and induced mitochondria-dependent apoptosis. Furthermore, Rg3-RGE also increased expression of mitophagy-related proteins such as PINK1 and Parkin. In addition, treatment with Rg3-RGE and mitophagy inhibitors stimulated cell death by inducing mitochondria dysfunction.
Conclusions: Rg3-RGE could be used as a therapeutic agent against lung cancer.
|
|
|
KEYWORD
|
|
|
Rg3-RGE (Rg3-enriched red ginseng extract), apoptosis, mitophagy, PINK1-parkin signaling
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|